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Title:

Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation.

Document type:
Journal Article
Author(s):
Aguiar Bucsai, Martina; Idel, Christian; Wollenberg, Barbara; Mannhalter, Christine; Verschoor, Admar
Abstract:
We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry. To do so, we used washed platelets from healthy human donors. We combined aggregometry, an assay of platelet functionality, with flow cytometry and ELISA to detect and correlate, respectively, platelet aggregation, activation, and granule release. While tirofiban effective...     »
Journal title abbreviation:
Platelets
Year:
2022
Journal volume:
33
Journal issue:
8
Pages contribution:
1192-1198
Fulltext / DOI:
doi:10.1080/09537104.2022.2078489
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35701857
Print-ISSN:
0953-7104
TUM Institution:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg)
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