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Title:

Therapy-Related Transcriptional Subtypes in Matched Primary and Recurrent Head and Neck Cancer.

Document type:
Journal Article
Author(s):
Weber, Peter; Künstner, Axel; Hess, Julia; Unger, Kristian; Marschner, Sebastian; Idel, Christian; Ribbat-Idel, Julika; Baumeister, Philipp; Gires, Olivier; Walz, Christoph; Rietzler, Sibylle; Valeanu, Laura; Herkommer, Timm; Kreutzer, Lisa; Klymenko, Olena; Drexler, Guido; Kirchner, Thomas; Maihöfer, Cornelius; Ganswindt, Ute; Walch, Axel; Sterr, Michael; Lickert, Heiko; Canis, Martin; Rades, Dirk; Perner, Sven; Berriel Diaz, Mauricio; Herzig, Stefan; Lauber, Kirsten; Wollenberg, Barbara; Busch...     »
Abstract:
PURPOSE: The genetic relatedness between primary and recurrent head and neck squamous cell carcinomas (HNSCC) reflects the extent of heterogeneity and therapy-driven selection of tumor subpopulations. Yet, current treatment of recurrent HNSCC ignores the molecular characteristics of therapy-resistant tumor populations. EXPERIMENTAL DESIGN: From 150 tumors, 74 primary HNSCCs were RNA sequenced and 38 matched primary/recurrent tumor pairs were both whole-exome and RNA sequenced. Transcriptome anal...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2022
Journal volume:
28
Journal issue:
5
Pages contribution:
1038-1052
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-21-2244
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34965946
Print-ISSN:
1078-0432
TUM Institution:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg)
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