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Titel:

Genome-Wide Gene Expression Analysis Reveals Unique Genes Signatures of Epithelial Reorganization in Primary Airway Epithelium Induced by Type-I, -II and -III Interferons.

Dokumenttyp:
Article; Journal Article
Autor(en):
Erb, Anna; Zissler, Ulrich M; Oelsner, Madlen; Chaker, Adam M; Schmidt-Weber, Carsten B; Jakwerth, Constanze A
Abstract:
Biosensors such as toll-like receptors (TLR) induce the expression of interferons (IFNs) after viral infection that are critical to the first step in cell-intrinsic host defense mechanisms. Their differential influence on epithelial integrity genes, however, remains elusive. A genome-wide gene expression biosensor chip for gene expression sensing was used to examine the effects of type-I, -II, and -III IFN stimulation on the epithelial expression profiles of primary organotypic 3D air-liquid int...     »
Zeitschriftentitel:
Biosensors (Basel)
Jahr:
2022
Band / Volume:
12
Heft / Issue:
11
Volltext / DOI:
doi:10.3390/bios12110929
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36354438
TUM Einrichtung:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg); Lehrstuhl für Molekulare Allergologie und Umweltforschung (Prof. Schmidt-Weber)
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