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Titel:

Biomarkers in Adult-Type Diffuse Gliomas: Elevated Levels of Circulating Vesicular Heat Shock Protein 70 Serve as a Biomarker in Grade 4 Glioblastoma and Increase NK Cell Frequencies in Grade 3 Glioma.

Dokumenttyp:
Journal Article
Autor(en):
Lennartz, Philipp; Thölke, Dennis; Bashiri Dezfouli, Ali; Pilz, Mathias; Lobinger, Dominik; Messner, Verena; Zanth, Hannah; Ainslie, Karen; Kafshgari, Morteza Hasanzadeh; Rammes, Gerhard; Ballmann, Markus; Schlegel, Martin; Foulds, Gemma Ann; Pockley, Alan Graham; Schmidt-Graf, Friederike; Multhoff, Gabriele
Abstract:
The presence of circulating Hsp70 levels and their influence on the immunophenotype of circulating lymphocyte subsets were examined as diagnostic/prognostic biomarkers for the overall survival (OS) in patients with IDH-mutant WHO grade 3 oligodendroglioma, astrocytoma, and IDH-wildtype grade 4 glioblastoma (GBM). Vesicular and free Hsp70 in the plasma/serum was measured using the Hsp70-exo and R&D; Systems DuoSet® Hsp70 ELISAs. The immunophenotype and membrane Hsp70 status was determined by multip...     »
Zeitschriftentitel:
Biomedicines
Jahr:
2023
Band / Volume:
11
Heft / Issue:
12
Volltext / DOI:
doi:10.3390/biomedicines11123235
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38137456
TUM Einrichtung:
Klinik für Anästhesiologie (DHM); Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg); Klinik und Poliklinik für Neurologie (Prof. Hemmer); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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