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Titel:

Therapy-Related Transcriptional Subtypes in Matched Primary and Recurrent Head and Neck Cancer.

Dokumenttyp:
Journal Article
Autor(en):
Weber, Peter; Künstner, Axel; Hess, Julia; Unger, Kristian; Marschner, Sebastian; Idel, Christian; Ribbat-Idel, Julika; Baumeister, Philipp; Gires, Olivier; Walz, Christoph; Rietzler, Sibylle; Valeanu, Laura; Herkommer, Timm; Kreutzer, Lisa; Klymenko, Olena; Drexler, Guido; Kirchner, Thomas; Maihöfer, Cornelius; Ganswindt, Ute; Walch, Axel; Sterr, Michael; Lickert, Heiko; Canis, Martin; Rades, Dirk; Perner, Sven; Berriel Diaz, Mauricio; Herzig, Stefan; Lauber, Kirsten; Wollenberg, Barbara; Busch...     »
Abstract:
PURPOSE: The genetic relatedness between primary and recurrent head and neck squamous cell carcinomas (HNSCC) reflects the extent of heterogeneity and therapy-driven selection of tumor subpopulations. Yet, current treatment of recurrent HNSCC ignores the molecular characteristics of therapy-resistant tumor populations. EXPERIMENTAL DESIGN: From 150 tumors, 74 primary HNSCCs were RNA sequenced and 38 matched primary/recurrent tumor pairs were both whole-exome and RNA sequenced. Transcriptome anal...     »
Zeitschriftentitel:
Clin Cancer Res
Jahr:
2022
Band / Volume:
28
Heft / Issue:
5
Seitenangaben Beitrag:
1038-1052
Volltext / DOI:
doi:10.1158/1078-0432.CCR-21-2244
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34965946
Print-ISSN:
1078-0432
TUM Einrichtung:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg)
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