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Titel:

Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation.

Dokumenttyp:
Journal Article
Autor(en):
Aguiar Bucsai, Martina; Idel, Christian; Wollenberg, Barbara; Mannhalter, Christine; Verschoor, Admar
Abstract:
We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry. To do so, we used washed platelets from healthy human donors. We combined aggregometry, an assay of platelet functionality, with flow cytometry and ELISA to detect and correlate, respectively, platelet aggregation, activation, and granule release. While tirofiban effective...     »
Zeitschriftentitel:
Platelets
Jahr:
2022
Band / Volume:
33
Heft / Issue:
8
Seitenangaben Beitrag:
1192-1198
Volltext / DOI:
doi:10.1080/09537104.2022.2078489
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35701857
Print-ISSN:
0953-7104
TUM Einrichtung:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg)
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