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Titel:

Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects.

Dokumenttyp:
Journal Article
Autor(en):
Wang, Jingbo; Joseph, Sabitha; Vingill, Siv; Dere, Ekrem; Tatenhorst, Lars; Ronnenberg, Anja; Lingor, Paul; Preisinger, Christian; Ehrenreich, Hannelore; Schulz, Jörg B; Stegmüller, Judith
Abstract:
Mutations in PARK15, which encodes for the F-box protein FBXO7 have been associated with Parkinsonian Pyramidal syndrome, a rare and complex movement disorder with Parkinsonian symptoms, pyramidal tract signs and juvenile onset. Our previous study showed that systemic loss of Fbxo7 in mice causes motor defects and premature death. We have also demonstrated that FBXO7 has a crucial role in neurons as the specific deletion in tyrosine hydroxylase-positive or glutamatergic forebrain neurons leads t...     »
Zeitschriftentitel:
J Neurochem
Jahr:
2023
Band / Volume:
167
Heft / Issue:
2
Seitenangaben Beitrag:
296-317
Volltext / DOI:
doi:10.1111/jnc.15962
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37753846
Print-ISSN:
0022-3042
TUM Einrichtung:
Klinik und Poliklinik für Neurologie (Prof. Hemmer)
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