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Title:

Glioblastoma Relapses Show Increased Markers of Vulnerability to Ferroptosis.

Document type:
Journal Article
Author(s):
Kram, Helena; Prokop, Georg; Haller, Bernhard; Gempt, Jens; Wu, Yang; Schmidt-Graf, Friederike; Schlegel, Jürgen; Conrad, Marcus; Liesche-Starnecker, Friederike
Abstract:
BACKGROUND: Despite the availability of various therapy options and being a widely focused research area, the prognosis of glioblastoma (GBM) still remains very poor due to therapy resistance, genetic heterogeneity and a diffuse infiltration pattern. The recently described non-apoptotic form of cell death ferroptosis may, however, offer novel opportunities for targeted therapies. Hence, the aim of this study was to investigate the potential role of ferroptosis in GBM, including the impact of tre...     »
Journal title abbreviation:
Front Oncol
Year:
2022
Journal volume:
12
Fulltext / DOI:
doi:10.3389/fonc.2022.841418
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35530303
Print-ISSN:
2234-943X
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für KI und Informatik in der Medizin (Prof. Rückert); Klinik und Poliklinik für Neurochirurgie (Prof. Meyer); Klinik und Poliklinik für Neurologie (Prof. Hemmer); Lehrstuhl für Medizinische Informatik (Prof. Boeker)
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