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- Title:
Population pharmacokinetics and dosing simulations of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis.
- Document type:
- Journal Article; Observational Study; Research Support, Non-U.S. Gov't
- Author(s):
- König, Christina; Braune, Stephan; Roberts, Jason A; Nierhaus, Axel; Steinmetz, Oliver M; Baehr, Michael; Frey, Otto R; Langebrake, Claudia; Kluge, Stefan
- Abstract:
- To describe the population PKs of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis (SLED).This study was performed in ICUs of a university hospital. We collected blood samples during three consecutive days of SLED sessions in patients receiving ceftazidime. Concentration versus time curves were analysed using a population PKs approach with Pmetrics ® . Monte Carlo simulation for the first 24 h including a 6 h SLED session was performed with the final model. The fractional target attainment against the MIC of Pseudomonas aeruginosa was executed using targets of 50 and 100% fT > MIC .In total, 211 blood samples of 16 critically ill patients under SLED were collected. SLED treatments were 299.3 (68.4) min in duration. A two-compartment linear population PK model was most appropriate. The mean (SD) CL of ceftazidime on SLED, and off SLED were 5.32 (3.2), 1.06 (1.0) L/h respectively. The PTA for 50% fT > MIC for a dose of 1 g intravenously every 8 h was 98%. Assuming a target of 100% fT > MIC a dose of 2 g every 12 h covers isolates with MIC <=8 mg/L with a PTA of 96%.In critically ill patients receiving SLED, ceftazidime 1 g every 8 h and ceftazidime 2 g every 12 h appear to be sufficient for achieving traditional (50% fT > MIC ) and aggressive PD targets (100% fT > MIC ) for susceptible isolates (MIC <=8 mg/L), respectively.
- Journal title abbreviation:
- J Antimicrob Chemother
- Year:
- 2017
- Journal volume:
- 72
- Journal issue:
- 5
- Pages contribution:
- 1433-1440
- Language:
- eng
- Fulltext / DOI:
- doi:10.1093/jac/dkw592
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/28175308
- Print-ISSN:
- 0305-7453
- TUM Institution:
- Neurologische Klinik und Poliklinik
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