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Titel:

CNS Aquaporin-4-specific B cells connect with multiple B-cell compartments in neuromyelitis optica spectrum disorder.

Dokumenttyp:
Journal Article
Autor(en):
Kowarik, Markus C; Astling, David; Gasperi, Christiane; Wemlinger, Scott; Schumann, Hannah; Dzieciatkowska, Monika; Ritchie, Alanna M; Hemmer, Bernhard; Owens, Gregory P; Bennett, Jeffrey L
Abstract:
Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory disorder of the central nervous system (CNS) targeted against aquaporin-4 (AQP4). The origin and trafficking of AQP4-specific B cells in NMOSD remains unknown.Peripheral (n = 7) and splenic B cells (n = 1) recovered from seven NMOSD patients were sorted into plasmablasts, naïve, memory, and CD27-IgD- double negative (DN) B cells, and variable heavy chain (VH) transcriptome sequences were generated by deep sequencing. Periphe...     »
Zeitschriftentitel:
Ann Clin Transl Neurol
Jahr:
2017
Band / Volume:
4
Heft / Issue:
6
Seitenangaben Beitrag:
369-380
Sprache:
eng
Volltext / DOI:
doi:10.1002/acn3.418
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28589164
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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