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Titel:

Specific Induction of Double Negative B Cells During Protective and Pathogenic Immune Responses.

Dokumenttyp:
Article; Journal Article
Autor(en):
Ruschil, Christoph; Gabernet, Gisela; Lepennetier, Gildas; Heumos, Simon; Kaminski, Miriam; Hracsko, Zsuzsanna; Irmler, Martin; Beckers, Johannes; Ziemann, Ulf; Nahnsen, Sven; Owens, Gregory P; Bennett, Jeffrey L; Hemmer, Bernhard; Kowarik, Markus C
Abstract:
Double negative (DN) (CD19+CD20lowCD27-IgD-) B cells are expanded in patients with autoimmune and infectious diseases; however their role in the humoral immune response remains unclear. Using systematic flow cytometric analyses of peripheral blood B cell subsets, we observed an inflated DN B cell population in patients with variety of active inflammatory conditions: myasthenia gravis, Guillain-Barré syndrome, neuromyelitis optica spectrum disorder, meningitis/encephalitis, and rheumatic disorde...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2020
Band / Volume:
11
Volltext / DOI:
doi:10.3389/fimmu.2020.606338
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33391273
Print-ISSN:
1664-3224
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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