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Document type:
Article; Journal Article
Author(s):
Samarelli, Anna V; Ziegler, Tilman; Meves, Alexander; Fässler, Reinhard; Böttcher, Ralph T
Title:
Rabgap1 promotes recycling of active β1 integrins to support effective cell migration.
Abstract:
Integrin function depends on the continuous internalization of integrins and their subsequent endosomal recycling to the plasma membrane to drive adhesion dynamics, cell migration and invasion. Here we assign a pivotal role for Rabgap1 (GAPCenA) in the recycling of endocytosed active β1 integrins to the plasma membrane. The phosphotyrosine-binding (PTB) domain of Rabgap1 binds to the membrane-proximal NPxY motif in the cytoplasmic domain of β1 integrin subunits on endosomes. Silencing Rabgap1 in...     »
Journal title abbreviation:
J Cell Sci
Year:
2020
Journal volume:
133
Journal issue:
18
Fulltext / DOI:
doi:10.1242/jcs.243683
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32843574
Print-ISSN:
0021-9533
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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