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Title:

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors.

Document type:
Journal Article
Author(s):
Poch, Christine M; Foo, Kylie S; De Angelis, Maria Teresa; Jennbacken, Karin; Santamaria, Gianluca; Bähr, Andrea; Wang, Qing-Dong; Reiter, Franziska; Hornaschewitz, Nadja; Zawada, Dorota; Bozoglu, Tarik; My, Ilaria; Meier, Anna; Dorn, Tatjana; Hege, Simon; Lehtinen, Miia L; Tsoi, Yat Long; Hovdal, Daniel; Hyllner, Johan; Schwarz, Sascha; Sudhop, Stefanie; Jurisch, Victoria; Sini, Marcella; Fellows, Mick D; Cummings, Matthew; Clarke, Jonathan; Baptista, Ricardo; Eroglu, Elif; Wolf, Eckhard; Klymi...     »
Abstract:
Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host-graft crosstalk remains elusive. Here, by combining lineage tracing and single-cell transcriptomics in injured non-human primate heart biomimics, we uncover the coordinated action modes of human progenitor-mediated muscle repair. Chemoattraction via CXCL12/CXCR4 directs cellular migr...     »
Journal title abbreviation:
Nat Cell Biol
Year:
2022
Journal volume:
24
Journal issue:
5
Pages contribution:
659-671
Fulltext / DOI:
doi:10.1038/s41556-022-00899-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35550611
Print-ISSN:
1465-7392
TUM Institution:
1693; Arbeitsgruppe Tissue Engineering und Regenerative Medizin; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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