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Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Klems, Alina; van Rijssel, Jos; Ramms, Anne S; Wild, Raphael; Hammer, Julia; Merkel, Melanie; Derenbach, Laura; Préau, Laetitia; Hinkel, Rabea; Suarez-Martinez, Irina; Schulte-Merker, Stefan; Vidal, Ramon; Sauer, Sascha; Kivelä, Riikka; Alitalo, Kari; Kupatt, Christian; van Buul, Jaap D; le Noble, Ferdinand
Titel:
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Abstract:
Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the transition of a growing artery with a small diameter into a large caliber artery with a sizeable diameter occurs upon the blood flow driven change in number and shape of endothelial cells lining the arterial lumen. Here, using zebrafish embryos and endothelial cell models, we describe an alternative, flow independent model, involving enlargement of arterial endothelial...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2020
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-020-19008-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33087700
Print-ISSN:
2041-1723
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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