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Title:

The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling.

Document type:
Article; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Author(s):
Lee, Min-Ah; Raad, Nour; Song, Min Ho; Yoo, Jimeen; Lee, Miyoung; Jang, Seung Pil; Kwak, Tae Hwan; Kook, Hyun; Choi, Eun-Kyoung; Cha, Tae-Joon; Hajjar, Roger J; Jeong, Dongtak; Park, Woo Jin
Abstract:
Atrial structural remodelling including atrial hypertrophy and fibrosis is a key mediator of atrial fibrillation (AF). We previously demonstrated that the matricellular protein CCN5 elicits anti-fibrotic and anti-hypertrophic effects in left ventricles under pressure overload. We here determined the utility of CCN5 in ameliorating adverse atrial remodelling and arrhythmias in a murine model of angiotensin II (AngII) infusion. Advanced atrial structural remodelling was induced by AngII infusion i...     »
Journal title abbreviation:
J Cell Mol Med
Year:
2020
Journal volume:
24
Journal issue:
20
Pages contribution:
11768-11778
Fulltext / DOI:
doi:10.1111/jcmm.15789
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32885578
Print-ISSN:
1582-1838
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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