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Title:

A decade of experience with genetically tailored pig models for diabetes and metabolic research.

Document type:
Article; Proceedings Paper; Journal Article; Review
Author(s):
Zettler, Silja; Renner, Simone; Kemter, Elisabeth; Hinrichs, Arne; Klymiuk, Nikolai; Backman, Mattias; Riedel, Evamaria Olga; Mueller, Christiane; Streckel, Elisabeth; Braun-Reichhart, Christina; Martins, Ana Sofia; Kurome, Mayuko; Keßler, Barbara; Zakhartchenko, Valeri; Flenkenthaler, Florian; Arnold, Georg Josef; Fröhlich, Thomas; Blum, Helmut; Blutke, Andreas; Wanke, Rüdiger; Wolf, Eckhard
Abstract:
The global prevalence of diabetes mellitus and other metabolic diseases is rapidly increasing. Animal models play pivotal roles in unravelling disease mechanisms and developing and testing therapeutic strategies. Rodents are the most widely used animal models but may have limitations in their resemblance to human disease mechanisms and phenotypes. Findings in rodent models are consequently often difficult to extrapolate to human clinical trials. To overcome this 'translational gap', we and other...     »
Journal title abbreviation:
Anim Reprod
Year:
2020
Journal volume:
17
Journal issue:
3
Fulltext / DOI:
doi:10.1590/1984-3143-AR2020-0064
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33029223
Print-ISSN:
1806-9614
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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