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Title:

Progressive Proteome Changes in the Myocardium of a Pig Model for Duchenne Muscular Dystrophy.

Document type:
Article; Journal Article
Author(s):
Tamiyakul, Hathaichanok; Kemter, Elisabeth; Kösters, Miwako; Ebner, Stefanie; Blutke, Andreas; Klymiuk, Nikolai; Flenkenthaler, Florian; Wolf, Eckhard; Arnold, Georg J; Fröhlich, Thomas
Abstract:
Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is characterized by progressive muscle weakness. Even though DMD manifests first in skeletal muscle, heart failure is a major cause of death in late-stage DMD. To get insights into DMD-associated cardiomyopathy, we performed a proteome analysis of myocardium from a genetically engineered porcine DMD model resembling clinical and pathological hallmarks of human DMD. To capture DMD progression, samples from 2-day- and 3...     »
Journal title abbreviation:
iScience
Year:
2020
Journal volume:
23
Journal issue:
9
Fulltext / DOI:
doi:10.1016/j.isci.2020.101516
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32927262
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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