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Title:

Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish.

Document type:
Article; Journal Article
Author(s):
Burczyk, Martina S; Burkhalter, Martin D; Tena, Teresa Casar; Grisanti, Laurel A; Kauk, Michael; Matysik, Sabrina; Donow, Cornelia; Kustermann, Monika; Rothe, Melanie; Cui, Yinghong; Raad, Farah; Laue, Svenja; Moretti, Allessandra; Zimmermann, Wolfram-H; Wess, Jürgen; Kühl, Michael; Hoffmann, Carsten; Tilley, Douglas G; Philipp, Melanie
Abstract:
Deterioration or inborn malformations of the cardiac conduction system (CCS) interfere with proper impulse propagation in the heart and may lead to sudden cardiac death or heart failure. Patients afflicted with arrhythmia depend on antiarrhythmic medication or invasive therapy, such as pacemaker implantation. An ideal way to treat these patients would be CCS tissue restoration. This, however, requires precise knowledge regarding the molecular mechanisms underlying CCS development. Here, we aimed...     »
Journal title abbreviation:
JCI Insight
Year:
2019
Journal volume:
4
Journal issue:
20
Fulltext / DOI:
doi:10.1172/jci.insight.121971
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31619590
Print-ISSN:
2379-3708
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin
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