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Titel:

Age- and Weight-Adapted Dose of Prasugrel Versus Standard Dose of Ticagrelor in Patients With Acute Coronary Syndromes : Results From a Randomized Trial.

Dokumenttyp:
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Autor(en):
Menichelli, Maurizio; Neumann, Franz-Josef; Ndrepepa, Gjin; Mayer, Katharina; Wöhrle, Jochen; Bernlochner, Isabell; Richardt, Gert; Witzenbichler, Bernhard; Sibbing, Dirk; Gewalt, Senta; Angiolillo, Dominick J; Lahu, Shqipdona; Hamm, Christian W; Hapfelmeier, Alexander; Trenk, Dietmar; Laugwitz, Karl-Ludwig; Schunkert, Heribert; Schüpke, Stefanie; Kastrati, Adnan
Abstract:
BACKGROUND: The efficacy and safety of a reduced dose of prasugrel versus a standard dose of ticagrelor in elderly patients or those with a low body weight presenting with an acute coronary syndrome (ACS) are unknown. OBJECTIVE: To investigate the effect of an age- and weight-adapted dose of prasugrel versus a standard dose of ticagrelor in patients with ACS. (ClinicalTrials.gov: NCT01944800). DESIGN: Prespecified analysis of the multicenter, randomized ISAR-REACT 5 trial. SETTING: 23 centers in...     »
Zeitschriftentitel:
Ann Intern Med
Jahr:
2020
Band / Volume:
173
Heft / Issue:
6
Seitenangaben Beitrag:
436-444
Volltext / DOI:
doi:10.7326/M20-1806
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32687741
Print-ISSN:
0003-4819
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Medizinische Statistik und Epidemiologie; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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