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Titel:

The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions.

Dokumenttyp:
Journal Article; Article
Autor(en):
Schafer, A; Schulz, C; Fraccarollo, D; Tas, P; Leutke, M; Eigenthaler, M; Seidl, S; Heider, P; Ertl, G; Massberg, S; Bauersachs, J
Abstract:
OBJECTIVE: The chemokine fractalkine activates platelets and induces leukocyte adhesion to the endothelium. Expression of fractalkine and its receptor, CX3CR1, is elevated in coronary artery disease. We assessed the effects of fractalkine on vascular function in isolated rat aorta. METHODS AND RESULTS: CX3CR1 expression was demonstrated in rat aortic endothelial and smooth muscle cells by immunohistochemistry, Western blot, and polymerase chain reaction (PCR). Fractalkine (up to 1 microg/mL) did...     »
Zeitschriftentitel:
Arterioscler Thromb Vasc Biol
Jahr:
2007
Band / Volume:
27
Heft / Issue:
1
Seitenangaben Beitrag:
55-62
Sprache:
eng
Volltext / DOI:
doi:10.1161/01.ATV.0000251535.30191.60
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17082482
Print-ISSN:
1079-5642
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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