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Titel:

Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction.

Dokumenttyp:
Article; Early Access
Autor(en):
Kunzke, Thomas; Buck, Achim; Prade, Verena M.; Feuchtinger, Annette; Prokopchuk, Olga; Martignoni, Marc E.; Heisz, Simone; Hauner, Hans; Janssen, Klaus-Peter; Walch, Axel; Aichler, Michaela
Abstract:
BACKGROUND: Cachexia is the direct cause of at least 20% of cancer-associated deaths. Muscle wasting in skeletal muscle results in weakness, immobility, and death secondary to impaired respiratory muscle function. Muscle proteins are massively degraded in cachexia; nevertheless, the molecular mechanisms related to this process are poorly understood. Previous studies have reported conflicting results regarding the amino acid abundances in cachectic skeletal muscle tissues. There is a clear need...     »
Zeitschriftentitel:
J Cachexia Sarcopenia Muscle
Jahr:
2020
Band / Volume:
11
Heft / Issue:
1
Seitenangaben Beitrag:
226-240
Volltext / DOI:
doi:10.1002/jcsm.12498
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31965747
Print-ISSN:
2190-5991
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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