User: Guest  Login
Title:

Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells.

Document type:
Journal Article
Author(s):
Mota Reyes, Carmen; Teller, Steffen; Muckenhuber, Alexander; Konukiewitz, Björn; Safak, Okan; Weichert, Wilko; Friess, Helmut; Ceyhan, Güralp O; Demir, Ihsan Ekin
Abstract:
PURPOSE: Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma, yet its mechanisms of action on tumor cells and the tumor microenvironment are still unknown. Here, we aimed to characterize the multiple facets of neoTx-induced alterations in the pancreatic cancer microenvironment. EXPERIMENTAL DESIGN: We performed the currently most comprehensive histopathologic analysis of desmoplasia, angi...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2020
Journal volume:
26
Journal issue:
1
Pages contribution:
220-231
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-19-1864
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31585935
Print-ISSN:
1078-0432
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX