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Title:

Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Cheng, Zhangjun; Lei, Zhengqing; Yang, Pinghua; Si, Anfeng; Xiang, Daimin; Tang, Xuewu; Guo, Guangmeng; Zhou, Jiahua; Hüser, Norbert
Abstract:
Hepatocellular carcinoma (HCC) is a fatal disease with increasing morbidity and poor prognosis due to surgical recurrence and metastasis. Moreover, the molecular mechanism of HCC progression remains unclear. Although the role of p120-catenin (p120ctn) in liver cancer is well studied, the effects of secreted p120ctn transported by exosomes are less understood. Here, we show that p120ctn in exosomes secreted from liver cancer cells suppresses HCC cell proliferation and metastasis and expansion of...     »
Journal title abbreviation:
Mol Carcinog
Year:
2019
Journal volume:
58
Journal issue:
8
Pages contribution:
1389-1399
Fulltext / DOI:
doi:10.1002/mc.23022
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30997702
Print-ISSN:
0899-1987
TUM Institution:
Chirurgische Klinik und Poliklinik
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