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Title:

Bone marrow expands the repertoire of functional T cells targeting tumor-associated antigens in patients with resectable non-small-cell lung cancer.

Document type:
Article; Journal Article
Author(s):
Safi, Seyer; Yamauchi, Yoshikane; Stamova, Slava; Rathinasamy, Anchana; Op den Winkel, Jan; Jünger, Simone; Bucur, Mariana; Umansky, Ludmilla; Warth, Arne; Herpel, Esther; Eichhorn, Martin; Winter, Hauke; Hoffmann, Hans; Beckhove, Philipp
Abstract:
The efficacy of cancer immunotherapy may be improved by increasing the number of circulating tumor-reactive T cells. The bone marrow is a priming site and reservoir for such T cells. The characteristics of bone marrow-derived tumor-reactive T cells are poorly understood in patients with non-small-cell lung cancer (NSCLC). To compare the responsiveness of tumor antigen-reactive T cells from the bone marrow with matched peripheral blood samples in patients with resectable NSCLC, we used flow cytom...     »
Journal title abbreviation:
Oncoimmunology
Year:
2019
Journal volume:
8
Journal issue:
12
Fulltext / DOI:
doi:10.1080/2162402X.2019.1671762
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31741774
Print-ISSN:
2162-4011
TUM Institution:
Klinik und Poliklinik für Chirurgie
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