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Title:

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Polykratis, Apostolos; Martens, Arne; Eren, Remzi Onur; Shirasaki, Yoshitaka; Yamagishi, Mai; Yamaguchi, Yoshifumi; Uemura, Sotaro; Miura, Masayuki; Holzmann, Bernhard; Kollias, George; Armaka, Marietta; van Loo, Geert; Pasparakis, Manolis
Abstract:
Deficiency in the deubiquitinating enzyme A20 causes severe inflammation in mice, and impaired A20 function is associated with human inflammatory diseases. A20 has been implicated in negatively regulating NF-κB signalling, cell death and inflammasome activation; however, the mechanisms by which A20 inhibits inflammation in vivo remain poorly understood. Genetic studies in mice revealed that its deubiquitinase activity is not essential for A20 anti-inflammatory function. Here we show that A20 pr...     »
Journal title abbreviation:
Nat Cell Biol
Year:
2019
Journal volume:
21
Journal issue:
6
Pages contribution:
731-742
Fulltext / DOI:
doi:10.1038/s41556-019-0324-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31086261
Print-ISSN:
1465-7392
TUM Institution:
Chirurgische Klinik und Poliklinik
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