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Title:

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.

Document type:
Journal Article; Article
Author(s):
Lesina, Marina; Wörmann, Sonja Maria; Morton, Jennifer; Diakopoulos, Kalliope Nina; Korneeva, Olga; Wimmer, Margit; Einwächter, Henrik; Sperveslage, Jan; Demir, Ihsan Ekin; Kehl, Timo; Saur, Dieter; Sipos, Bence; Heikenwälder, Mathias; Steiner, Jörg Manfred; Wang, Timothy Cragin; Sansom, Owen J; Schmid, Roland Michael; Algül, Hana
Abstract:
Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here, we have determined that nuclear RelA reinforces OIS to inhibit carcinogenesis in the Kras mouse model of PDAC. Inactivation of RelA accelerated pancreatic lesion formation in Kras mice by abrogating the senescence-associated secretory phenotype...     »
Journal title abbreviation:
J Clin Invest
Year:
2016
Journal volume:
126
Journal issue:
8
Pages contribution:
2919-32
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI86477
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27454298
Print-ISSN:
0021-9738
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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