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Title:

A quantitative LC-MS/MS approach for monitoring 2'-fluoro-2'-deoxy-D-glucose uptake in tumor tissue.

Document type:
Article; Journal Article
Author(s):
Li, Wenlin; Zhang, Cathy; Huser, Nanni; Ray, Chad; Fountain, Scott; Kindt, Erick
Abstract:
Purpose: Develop a quantitative LC-MS/MS method for FDG, FDG-monophosphate, glucose and glucose-monophosphate in mouse tumor models to assist in validating the use of [18F]FDG-positron emission tomography (PET) imaging for anticancer therapies in a clinical setting. Methodology/results: Analytes were isolated from tumors by protein precipitation and detected on a Sciex API-5500 mass spectrometer. Improved assay robustness and selectivity were achieved through chromatographic separation of FDG-mo...     »
Journal title abbreviation:
Bioanalysis
Year:
2021
Journal volume:
13
Journal issue:
6
Pages contribution:
481-491
Fulltext / DOI:
doi:10.4155/bio-2020-0326
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33724050
Print-ISSN:
1757-6180
TUM Institution:
Klinik und Poliklinik für Chirurgie
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