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Titel:

Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Cheng, Zhangjun; Lei, Zhengqing; Yang, Pinghua; Si, Anfeng; Xiang, Daimin; Tang, Xuewu; Guo, Guangmeng; Zhou, Jiahua; Hüser, Norbert
Abstract:
Hepatocellular carcinoma (HCC) is a fatal disease with increasing morbidity and poor prognosis due to surgical recurrence and metastasis. Moreover, the molecular mechanism of HCC progression remains unclear. Although the role of p120-catenin (p120ctn) in liver cancer is well studied, the effects of secreted p120ctn transported by exosomes are less understood. Here, we show that p120ctn in exosomes secreted from liver cancer cells suppresses HCC cell proliferation and metastasis and expansion of...     »
Zeitschriftentitel:
Mol Carcinog
Jahr:
2019
Band / Volume:
58
Heft / Issue:
8
Seitenangaben Beitrag:
1389-1399
Volltext / DOI:
doi:10.1002/mc.23022
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30997702
Print-ISSN:
0899-1987
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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