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- Original title:
- Structural and functional characterization of RBM5/6/10 in alternative splicing regulation
- Translated title:
- Strukturelle und funktionale Charakterisierung von RBM5,6 und 10 in der Regulation von alternativem Spleißen
- Author:
- Soni, Komal
- Year:
- 2017
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Chemie
- Advisor:
- Sattler, Michael (Prof. Dr.)
- Referee:
- Sattler, Michael (Prof. Dr.); Niessing, Dierk (Prof. Dr.)
- Language:
- en
- Subject group:
- CHE Chemie
- Keywords:
- RBM5, alternative splicing
- Translated keywords:
- RBM5, alternatives Spleißen
- TUM classification:
- CHE 808d; CHE 244d
- Abstract:
- The multi-domain RNA Binding Motif (RBM) proteins RBM5/6/10 modulate alternative splicing of apoptosis linked pre-mRNAs. Structural mechanisms are presented for the interactions of the RBM5/6/10 OCRE domain and the spliceosomal snRNPs; and of RRM and zinc finger domains with cis-regulatory RNA elements in pre-mRNAs of target genes for which alternative splicing is controlled by RBM5.
- Translated abstract:
- RBM5/6/10 sind Multidomänen RNA Bindemotifproteine, die alternatives Spleißen von Apoptose assoziierten mRNAs regulieren. Die vorliegende Arbeit zeigt Einblicke in strukturelle Mechanismen der OCRE RBM5/6/10 Interaktion mit spleißosomalen snRNPs. Darüber hinaus werden die Bindung von RRMs und Zinkfingerdomänen mit cis-regulatorischen RNA-Elementen aus pre-mRNAs untersucht, die RBM5 reguliert.
- WWW:
- https://mediatum.ub.tum.de/?id=1363180
- Date of submission:
- 19.06.2017
- Oral examination:
- 17.07.2017
- File size:
- 10836062 bytes
- Pages:
- 220
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20170717-1363180-1-7
- Last change:
- 17.07.2018
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