Combined proteomics and CRISPR Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo
Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Bahrami, Ehsan ; Schmid, Jan Philipp ; Jurinovic, Vindi ; Becker, Martin ; Wirth, Anna-Katharina ; Ludwig, Romina ; Kreissig, Sophie ; Duque Angel, Tania Vanessa ; Amend, Diana ; Hunt, Katharina ; Öllinger, Rupert ; Rad, Roland ; Frenz, Joris Maximilian ; Solovey, Maria ; Ziemann, Frank ; Mann, Matthias ; Vick, Binje ; Wichmann, Christian ; Herold, Tobias ; Jayavelu, Ashok Kumar ; Jeremias, Irmela
Stichworte:
Research ; Genome Editing and the Future of Personalized and Targeted Cancer Medicine ; CRISPR-Cas9 in vivo screen ; Proteomics ; ADAM10 ; PDX ; Acute leukemia ; Leukemia stem cells ; Medical and Health Sciences
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