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Titel:

The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.

Dokumenttyp:
Article; Journal Article
Autor(en):
Ramberger, Evelyn; Sapozhnikova, Valeriia; Ng, Yuen Lam Dora; Dolnik, Anna; Ziehm, Matthias; Popp, Oliver; Sträng, Eric; Kull, Miriam; Grünschläger, Florian; Krüger, Josefine; Benary, Manuela; Müller, Sina; Gao, Xiang; Murgai, Arunima; Haji, Mohamed; Schmidt, Annika; Lutz, Raphael; Nogai, Axel; Braune, Jan; Laue, Dominik; Langer, Christian; Khandanpour, Cyrus; Bassermann, Florian; Döhner, Hartmut; Engelhardt, Monika; Straka, Christian; Hundemer, Michael; Beule, Dieter; Haas, Simon; Keller, Ulric...     »
Abstract:
Multiple myeloma (MM) is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, MM remains incurable, and better risk stratification as well as new therapies are therefore highly needed. The proteome of MM has not been systematically assessed before and holds the potential to uncover insight into disease biology and improved prognostication in addition to genetic and transcriptomic studies. Here we provide a comprehensive multiomics analysis including deep tandem mass tag-bas...     »
Zeitschriftentitel:
Nat. Cancer
Jahr:
2024
Band / Volume:
5
Heft / Issue:
8
Seitenangaben Beitrag:
1267-1284
Volltext / DOI:
doi:10.1038/s43018-024-00784-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38942927
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann)
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