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Titel:

Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors.

Dokumenttyp:
Journal Article
Autor(en):
Kuehn, Julia C; Metzger, Patrick; Neidert, Nicolas; Matysiak, Uta; Gräßel, Linda; Philipp, Ulrike; Bleul, Sabine; Pauli, Thomas; Falkenstein, Julia; Bertemes, Henriette; Cysar, Stepan; Hess, Maria Elena; Frey, Anna Verena; Duque-Afonso, Jesús; Schorb, Elisabeth; Machein, Marcia; Beck, Jürgen; Schnell, Oliver; von Bubnoff, Nikolas; Illert, Anna L; Peters, Christoph; Brummer, Tilman; Prinz, Marco; Miething, Cornelius; Becker, Heiko; Lassmann, Silke; Werner, Martin; Börries, Melanie; Duyster, Justu...     »
Abstract:
Despite major advances in molecular profiling and classification of primary brain tumors, personalized treatment remains limited for most patients. Here, we explored the feasibility of individual molecular profiling and the efficacy of biomarker-guided therapy for adult patients with primary brain cancers in the real-world setting within the molecular tumor board Freiburg, Germany. We analyzed genetic profiles, personalized treatment recommendations, and clinical outcomes of 102 patients with 21...     »
Zeitschriftentitel:
npj Precis Oncol
Jahr:
2024
Band / Volume:
8
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41698-024-00674-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/39143272
Print-ISSN:
2397-768X
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann)
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