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Title:

The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.

Document type:
Article; Journal Article
Author(s):
Ramberger, Evelyn; Sapozhnikova, Valeriia; Ng, Yuen Lam Dora; Dolnik, Anna; Ziehm, Matthias; Popp, Oliver; Sträng, Eric; Kull, Miriam; Grünschläger, Florian; Krüger, Josefine; Benary, Manuela; Müller, Sina; Gao, Xiang; Murgai, Arunima; Haji, Mohamed; Schmidt, Annika; Lutz, Raphael; Nogai, Axel; Braune, Jan; Laue, Dominik; Langer, Christian; Khandanpour, Cyrus; Bassermann, Florian; Döhner, Hartmut; Engelhardt, Monika; Straka, Christian; Hundemer, Michael; Beule, Dieter; Haas, Simon; Keller, Ulric...     »
Abstract:
Multiple myeloma (MM) is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, MM remains incurable, and better risk stratification as well as new therapies are therefore highly needed. The proteome of MM has not been systematically assessed before and holds the potential to uncover insight into disease biology and improved prognostication in addition to genetic and transcriptomic studies. Here we provide a comprehensive multiomics analysis including deep tandem mass tag-bas...     »
Journal title abbreviation:
Nat. Cancer
Year:
2024
Journal volume:
5
Journal issue:
8
Pages contribution:
1267-1284
Fulltext / DOI:
doi:10.1038/s43018-024-00784-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38942927
TUM Institution:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann)
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