Login
- Dokumenttyp:
- Journal Article
- Autor(en):
- Allescher, Julia; Sinnecker, Daniel; von Goeldel, Bernhard; Barthel, Petra; Müller, Alexander; Hapfelmeier, Alexander; Martens, Eimo; Laugwitz, Karl-Ludwig; Schmidt, Georg; Steger, Alexander
- Titel:
- QRS fragmentation does not predict mortality in survivors of acute myocardial infarction.
- Abstract:
- BACKGROUND: Despite advances in coronary revascularization and in heart failure management, myocardial infarction survivors remain at substantially increased mortality risk. Precise risk assessment and risk-adapted follow-up care are crucial to improve their outcomes. Recently, the fragmented QRS complex, i.e. the presence of additional spikes within the QRS complexes on a 12-lead electrocardiogram, has been discussed as a potential non-invasive risk predictor in cardiac patients. HYPOTHESIS: The aim of this study was to evaluate the prognostic meaning of the fragmented QRS complex in myocardial infarction survivors. METHODS: 609 patients with narrow QRS complexes <120 ms were included in a prospective cohort study while hospitalized for myocardial infarction and followed for 5 years. RESULTS: The prevalence of the fragmented QRS complex in these patients amounted to 46.8% (285 patients). These patients had no increased hazard of all-cause death (HR 0.84, 95%-CI 0.45-1.57, p = 0.582) with a mortality rate of 6.0% compared to 7.1% in patients without QRS fragmentations. Furthermore, the risks of cardiac death (HR 1.28, 95%-CI 0.49-3.31, p = 0.613) and of non-cardiac death (HR 0.6, 95%-CI 0.26-1.43, p = 0.25) were not significantly different in patients with QRS fragmentations. However, patients with QRS fragmentations had increased serum creatine kinase concentrations (1438U/l vs. 1160U/l, p = 0.039) and reduced left ventricular ejection fractions (52% vs. 54%, p = 0.011). CONCLUSIONS: The hypothesis that QRS fragmentation might be a prognostic parameter in survivors of myocardial infarction was not confirmed. But those with QRS fragmentation had larger myocardial infarctions, as measured by creatine kinase and left ventricular ejection fraction.
- Zeitschriftentitel:
- Clin Cardiol
- Jahr:
- 2024
- Band / Volume:
- 47
- Heft / Issue:
- 1
- Volltext / DOI:
- doi:10.1002/clc.24218
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/38269630
- Print-ISSN:
- 0160-9289
- TUM Einrichtung:
- Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)
BibTeX