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- Title:
Natural History and Surgical Outcomes of Lamellar Macular Holes.
- Document type:
- Journal Article
- Author(s):
- Chehaibou, Ismael; Tadayoni, Ramin; Hubschman, Jean-Pierre; Bottoni, Ferdinando; Caputo, Georges; Chang, Stanley; Dell'Omo, Roberto; Figueroa, Marta S; Gaudric, Alain; Haritoglou, Christos; Kadonosono, Kazuaki; Leisser, Christoph; Maier, Mathias; Priglinger, Siegfried; Rizzo, Stanislao; Schumann, Ricarda G; Sebag, Jerry; Stamenkovic, Miroslav; Veckeneer, Marc; Steel, David H
- Abstract:
- PURPOSE: To assess the natural history and surgical outcomes of lamellar macular holes (LMHs). DESIGN: Retrospective and consecutive case series. SUBJECTS: Patients with LMHs from multiple tertiary care centers. METHODS: Clinical charts and OCT scans were reviewed. MAIN OUTCOME MEASURES: The visual acuity (VA) changes and the occurrence rate of full-thickness macular hole (FTMH) were studied in both groups. Within the operated group, factors associated with 6-month VA and development of FTMH were explored. RESULTS: One hundred seventy-eight eyes were included, of which 89 were monitored and 89 underwent surgery. In the observation group, the mean VA decreased from 0.25 ± 0.18 to 0.28 ± 0.18 logarithm of the minimum angle of resolution (logMAR; P = 0.13), with 14 eyes (15.7%) that lost ≥ 0.2 logMAR VA, after 45.7 ± 33.3 months. Nine eyes (10.1%) spontaneously developed an FTMH. In the operated group, the mean VA increased from 0.47 ± 0.23 to 0.35 ± 0.25 logMAR at 6 months (P < 0.001) and 0.36 ± 0.28 logMAR (P = 0.001) after 24.1 ± 30.1 months. By multivariate analysis, better baseline VA (P < 0.001), the presence of an epiretinal membrane (P = 0.03), and the peeling of the internal limiting membrane (ILM; P = 0.02), with a greater effect of ILM perihole sparing, were associated with a greater 6-month VA. Perihole epiretinal proliferation sparing was associated with a better postoperative VA by univariate analysis (P = 0.03), but this was not significant by multivariate analysis. Eight eyes (9.0%) developed a postoperative FTMH. Using Cox proportional hazard ratios [HRs], pseudophakia at baseline (HR, 0.06; 95% confidence interval [CI], 0.00-0.75; P = 0.03) and peeling of the ILM (HR, 0.05; 95% CI, 0.01-0.39; P = 0.004) were protective factors, while ellipsoid zone disruption (HR, 10.5; 95% CI, 1.04-105; P = 0.05) was associated with an increased risk of FTMH. CONCLUSION: Observed eyes with LMH experienced, on average, progressive VA loss. Patients with LMH and altered vision may benefit from surgery. Internal limiting membrane peeling, with perihole ILM sparing, represents a crucial step of the surgery associated with a greater VA and a lower risk of postoperative FTMH. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
- Journal title abbreviation:
- Ophthalmol Retina
- Year:
- 2024
- Journal volume:
- 8
- Journal issue:
- 3
- Pages contribution:
- 210-222
- Fulltext / DOI:
- doi:10.1016/j.oret.2023.09.016
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/37743020
- Print-ISSN:
- 2468-7219
- TUM Institution:
- Klinik und Poliklinik für Augenheilkunde (Prof. Maier komm.)
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