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Titel:

A randomized, single ascending dose safety, tolerability and pharmacokinetics study of NicaPlant® in aneurysmal subarachnoid hemorrhage patients undergoing clipping.

Dokumenttyp:
Journal Article
Autor(en):
Kerschbaumer, Johannes; Freyschlag, Christian Franz; Petr, Ondra; Adage, Tiziana; Breitenbach J, Joerg; Wessels, Lars; Wolf, Stefan; Hecht, Nils; Gempt, Jens; Wostrack, Maria; Gmeiner, Matthias; Gollwitzer, Maria; Stefanits, Harald; Bendszus M, Martin; Gruber, Andreas; Meyer, Bernhard; Vajkoczy, Peter; Thomé, Claudius
Abstract:
INTRODUCTION: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality. Post-hemorrhagic vasospasm with neurological deterioration is a major concern in this context. NicaPlant®, a modified release formulation of the calcium channel blocker nicardipine, has shown vasodilator efficacy preclinically and a similar formulation known as NPRI has shown anti-vasospasm activity in aSAH patients under compassionate use. RESEARCH QUESTION: The study aimed to assess pharmac...     »
Zeitschriftentitel:
Brain Spine
Jahr:
2023
Band / Volume:
3
Volltext / DOI:
doi:10.1016/j.bas.2023.102673
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38021019
Print-ISSN:
2772-5294
TUM Einrichtung:
Klinik und Poliklinik für Neurochirurgie (Prof. Meyer)
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