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Titel:

msqrob2PTM: Differential Abundance and Differential Usage Analysis of MS-Based Proteomics Data at the Posttranslational Modification and Peptidoform Level.

Dokumenttyp:
Journal Article
Autor(en):
Demeulemeester, Nina; Gébelin, Marie; Caldi Gomes, Lucas; Lingor, Paul; Carapito, Christine; Martens, Lennart; Clement, Lieven
Abstract:
In the era of open-modification search engines, more posttranslational modifications than ever can be detected by LC-MS/MS-based proteomics. This development can switch proteomics research into a higher gear, as PTMs are key in many cellular pathways important in cell proliferation, migration, metastasis, and aging. However, despite these advances in modification identification, statistical methods for PTM-level quantification and differential analysis have yet to catch up. This absence can part...     »
Zeitschriftentitel:
Mol Cell Proteomics
Jahr:
2024
Band / Volume:
23
Heft / Issue:
2
Volltext / DOI:
doi:10.1016/j.mcpro.2023.100708
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38154689
Print-ISSN:
1535-9476
TUM Einrichtung:
Klinik und Poliklinik für Neurologie (Prof. Hemmer)
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