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Titel:

Identification of the unfolded protein response pathway as target for radiosensitization in pancreatic cancer.

Dokumenttyp:
Journal Article
Autor(en):
Kern, Jana; Schilling, Daniela; Schneeweis, Christian; Schmid, Roland M; Schneider, Günter; Combs, Stephanie E; Dobiasch, Sophie
Abstract:
BACKGROUND AND PURPOSE: Due to the high intrinsic radioresistance of pancreatic ductal adenocarcinoma (PDAC), radiotherapy (RT) is only beneficial in 30% of patients. Therefore, this study aimed to identify targets to improve the efficacy of RT in PDAC. MATERIALS AND METHODS: Alamar Blue proliferation and colony formation assay (CFA) were used to determine the radioresponse of a cohort of 38 murine PDAC cell lines. A gene set enrichment analysis was performed to reveal differentially expressed p...     »
Zeitschriftentitel:
Radiother Oncol
Jahr:
2024
Band / Volume:
191
Volltext / DOI:
doi:10.1016/j.radonc.2023.110059
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38135186
Print-ISSN:
0167-8140
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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