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Title:

Mepolizumab Reduces Systemic Corticosteroid Use in Chronic Rhinosinusitis With Nasal Polyps.

Document type:
Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Author(s):
Chupp, Geoffrey; Alobid, Isam; Lugogo, Njira L; Kariyawasam, Harsha H; Bourdin, Arnaud; Chaker, Adam M; Smith, Steven G; Sousa, Ana R; Mayer, Bhabita; Chan, Robert H; Matucci, Andrea
Abstract:
BACKGROUND: Systemic corticosteroids (SCSs) are associated with short- and long-term adverse effects. OBJECTIVE: To assess mepolizumab efficacy according to prior SCS use and characterize mepolizumab's SCS-sparing capabilities, in patients with severe chronic rhinosinusitis with nasal polyps. METHODS: In the randomized, double-blind, phase III SYNAPSE trial (NCT03085797), adults with severe chronic rhinosinusitis with nasal polyps eligible for repeat sinus surgery despite standard of care treatm...     »
Journal title abbreviation:
J Allergy Clin Immunol Pract
Year:
2023
Journal volume:
11
Journal issue:
11
Pages contribution:
3504-3512.e2
Fulltext / DOI:
doi:10.1016/j.jaip.2023.08.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37586475
Print-ISSN:
2213-2198
TUM Institution:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg)
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