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- Dokumenttyp:
- Article; Journal Article
- Autor(en):
- Pellegrini, Costanza; Garot, Philippe; Morice, Marie-Claude; Tamburino, Corrado; Bleiziffer, Sabine; Thiele, Holger; Scholtz, Smita; Schramm, Rene; Cockburn, James; Cunnington, Michael; Wolf, Alexander; Barbanti, Marco; Tchétché, Didier; Pagnotta, Paolo; Gilard, Martine; Bedogni, Francesco; Van Belle, Eric; Vasa-Nicotera, Mariuca; Chieffo, Alaide; Bogaerts, Kris; Hengstenberg, Christian; Capodanno, Davide; Joner, Michael
- Titel:
- Permanent pacemaker implantation and left bundle branch block with self-expanding valves - a SCOPE 2 subanalysis.
- Abstract:
- BACKGROUND: No detailed data on left bundle branch block (LBBB) and permanent pacemaker implantation (PPI) exist from randomised clinical trials comparing the ACURATE neo and CoreValve Evolut devices. AIMS: Our aim was to assess the incidence and impact of new LBBB and PPI with self-expanding prostheses from a powered randomised comparison. METHODS: From the SCOPE 2 trial, 648 patients with no previous pacemaker were analysed for PPI at 30 days, and 426 patients without previous LBBB were adopted for analysis of LBBB at 30 days. Results: At 30 days, 16.5% of patients required PPI; rates were higher in CoreValve Evolut compared to ACURATE neo recipients (21.0% vs 12.3%; p=0.004). Previous right bundle branch block (odds ratio [OR] 6.11, 95% confidence interval [CI]: 3.19-11.73; p<0.001) was associated with an increased risk of PPI at 30 days, whereas the use of the ACURATE neo (OR 0.50, 95% CI: 0.31-0.81; p=0.005) was associated with a decreased risk. One-year mortality was similar in patients with and without new PPI. A total of 9.4% of patients developed persistent LBBB at 30 days, with higher incidences in CoreValve Evolut recipients (13.4% vs 5.5%; p=0.007). New LBBB at 30 days was associated with lower ejection fraction at 1 year (65.7%±11.0 vs 69.1%±7.6; p=0.041). CONCLUSIONS: New LBBB and PPI rates were lower in ACURATE neo compared to CoreValve Evolut recipients. The ACURATE neo valve was associated with a lower risk of PPI at 30 days. No effect on 1-year mortality was determined for PPI at 30 days, while LBBB at 30 days was associated with reduced ejection fraction at 1 year.
- Zeitschriftentitel:
- EuroIntervention
- Jahr:
- 2023
- Band / Volume:
- 18
- Heft / Issue:
- 13
- Seitenangaben Beitrag:
- e1077-e1087
- Volltext / DOI:
- doi:10.4244/EIJ-D-22-00558
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/36128956
- Print-ISSN:
- 1774-024X
- TUM Einrichtung:
- Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)
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