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- Title:
Prediction of Clinically Significant Prostate Cancer Using Multiparametric MRI, Biparametric MRI, and Clinical Parameters.
- Document type:
- Journal Article
- Author(s):
- Oberneder, Maximilian; Henzler, Thomas; Kriegmair, Martin; Vag, Tibor; Roethke, Matthias; Siegert, Sabine; Lang, Roland; Lenk, Julia; Gawlitza, Joshua
- Abstract:
- INTRODUCTION: Multiparametric MRI (mpMRI) is gold standard for the primary diagnostic work-up of clinically significant prostate cancer (csPCa). The aim of this study was to assess the benefit of the perfusion sequence and the non-inferiority of an MRI without contrast administration (bpMRI) compared to mpMRI while taking clinical parameters into account. METHODS: In this retrospective, non-interventional study we examined MRI data from 355 biopsy-naïve patients, performed on a 3T MRI system, evaluated by a board-certified radiologist with over 10 years of experience with subsequent mpMRI-TRUS fusion biopsy. DISCUSSION: Only 16/355 (4.5%) patients benefited from dynamic contrast enhanced. In only 3/355 (0.8%) patients, csPCa would have been missed in bpMRI. BpMRI provided sensitivity and specificity (81.4%; 79.4%) comparable to mpMRI (75.2%; 81.8%). Additionally, bpMRI and mpMRI were independent predictors for the presence of csPCa, individually (OR: 15.36; p < 0.001 vs. 12.15; p = 0.006) and after accounting for established influencing factors (OR: 12.81; p < 0.001 vs. 6.50; p = 0.012). When clinical parameters were considered, a more balanced diagnostic performance between sensitivity and specificity was found for mpMRI and bpMRI. Overall, PSA density showed the highest diagnostic performance (area under the curve = 0.81) for the detection of csPCa. CONCLUSION: The premise of the study was confirmed. Therefore, bpMRI should be adopted as soon as existing limitations have been lifted by prospective multi-reader studies.
- Journal title abbreviation:
- Urol Int
- Year:
- 2024
- Pages contribution:
- 1-8
- Fulltext / DOI:
- doi:10.1159/000541152
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/39217986
- Print-ISSN:
- 0042-1138
- TUM Institution:
- Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)
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