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- Document type:
- Journal Article
- Author(s):
- Staudt, Anna; Jörres, Rudolf A; Hinterberger, Thilo; Lehnen, Nadine; Loew, Thomas; Budweiser, Stephan
- Title:
- Associations of Post-Acute COVID syndrome with physiological and clinical measures 10 months after hospitalization in patients of the first wave.
- Abstract:
- BACKGROUND: For a better understanding of the factors underlying the Post-Acute COVID Syndrome, we studied the relationship between symptoms and functional alterations in COVID-19 patients 10 months after hospitalization. METHODS: One-hundred-one patients hospitalized between March 1st and June 30th 2020 participated in a follow-up visit for an assessment of clinical history, comorbidities, lung function, physical capacity and symptoms, including the SGRQ for health-related quality of life, PHQ-9-D for depression, and SOMS-2 J for somatoform disorders. Data were analyzed by univariate comparisons and multiple logistic regression analyses. RESULTS: Median age was 60 years, 42% were female, 76% had at least one comorbidity, the median length of the hospital stay was 8 days, 19% had been on the ICU. The most prevalent symptoms included shortness of breath (49%), fatigue (49%) and cognitive impairment (39%). Signs of major depression (PHQ-9-D ≥ 10) occurred in 28%/2% (p < 0.05) of patients with/without self-reported cognitive impairment, with median total SGRQ score being 25.4/5.3 (p < 0.05). There were associations between shortness of breath and BMI, SGRQ and hemoglobin levels; between fatigue, SGRQ and PHQ-9-D; and between cognitive impairment and PHQ-9-D (p < 0.05 each) but not with lung function or physical capacity. Characteristics of the acute disease were not related to symptoms. CONCLUSIONS: The findings demonstrate that 10 months after discharge from a hospital stay due to COVID-19, the percentages of patients with symptoms were high. Symptoms showed a consistent pattern but could not be attributed to altered lung function or physical capacity. Our results suggest a role for alternative etiologies including psychosocial factors.
- Journal title abbreviation:
- Eur J Intern Med
- Year:
- 2022
- Journal volume:
- 95
- Pages contribution:
- 50-60
- Fulltext / DOI:
- doi:10.1016/j.ejim.2021.10.031
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/34838369
- Print-ISSN:
- 0953-6205
- TUM Institution:
- 587; Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
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