Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study.

Sadlonova, Monika; Senges, Jochen; Nagel, Jonas; Celano, Christopher; Klasen-Max, Caroline; Borggrefe, Martin; Akin, Ibrahim; Thomas, Dierk; Schwarzbach, Christopher Jan; Kleeman, Thomas; Schneider, Steffen; Hochadel, Matthias; Süselbeck, Tim; Schwacke, Harald; Alonso, Angelika; Haass, Markus; Ladwig, Karl-Heinz; Herrmann-Lingen, Christoph

doi:10.3390/jcm11041140

journal article

Document type:: Article; Journal Article
Author(s):: Sadlonova, Monika; Senges, Jochen; Nagel, Jonas; Celano, Christopher; Klasen-Max, Caroline; Borggrefe, Martin; Akin, Ibrahim; Thomas, Dierk; Schwarzbach, Christopher Jan; Kleeman, Thomas; Schneider, Steffen; Hochadel, Matthias; Süselbeck, Tim; Schwacke, Harald; Alonso, Angelika; Haass, Markus; Ladwig, Karl-Heinz; Herrmann-Lingen, Christoph
Title:: Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study.
Abstract:: BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with impaired health-related quality of life (HRQoL), high symptom severity, and poor cardiovascular outcomes. Both clinical and psychological factors may contribute to symptom severity and HRQoL in AF. METHODS: Using data from the observational Atrial Fibrillation Rhine-Neckar Region (ARENA) trial, we identified medical and psychosocial factors associated with AF-related symptom severity using European Heart Rhythm Association symptom classification and HRQoL using 5-level EuroQoL- 5D. RESULTS: In 1218 AF patients (mean age 71.1 ± 10.5 years, 34.5% female), female sex (OR 3.7, p < 0.001), preexisting coronary artery disease (CAD) (OR 1.7, p = 0.020), a history of cardioversion (OR 1.4, p = 0.041), cardiac anxiety (OR 1.2; p < 0.001), stress from noise (OR 1.4, p = 0.005), work-related stress (OR 1.3, p = 0.026), and sleep disturbance (OR 1.2, p = 0.016) were associated with higher AF-related symptom severity. CAD (β = -0.23, p = 0.001), diabetes mellitus (β = -0.25, p < 0.001), generalized anxiety (β = -0.30, p < 0.001), cardiac anxiety (β = -0.16, p < 0.001), financial stress (β = -0.11, p < 0.001), and sleep disturbance (β = 0.11, p < 0.001) were associated with impaired HRQoL. CONCLUSIONS: Psychological characteristics, preexisting CAD, and diabetes may play an important role in the identification of individuals at highest risk for impaired HRQoL and high symptom severity in patients with AF.
Journal title abbreviation:: J Clin Med
Year:: 2022
Journal volume:: 11
Journal issue:: 4
Fulltext / DOI:: doi:10.3390/jcm11041140
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/35207412
TUM Institution:: Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie (Prof. Henningsen)2022