DIRECT MACULAR HOLE MANIPULATION RESULTS IN HIGH SUCCESS RATE IN SECONDARY MACULAR HOLE REPAIR.

Schönbach, Etienne M; Knight, Darren K; Wu, Chris Y; Arevalo, J Fernando; Bittencourt de Souza, Luiza; Cheng, Lingyun; Chhablani, Jay; Delalibera Pacheco, Kátia; Feucht, Nikolaus; Kozak, Igor; Maia, André; Maier, Mathias; Roizenblatt, Marina; Smiddy, William E; Sobol, Warren M; Freeman, William R

doi:10.1097/IAE.0000000000003712

2023

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Title:: DIRECT MACULAR HOLE MANIPULATION RESULTS IN HIGH SUCCESS RATE IN SECONDARY MACULAR HOLE REPAIR.
Document type:: Journal Article
Author(s):: Schönbach, Etienne M; Knight, Darren K; Wu, Chris Y; Arevalo, J Fernando; Bittencourt de Souza, Luiza; Cheng, Lingyun; Chhablani, Jay; Delalibera Pacheco, Kátia; Feucht, Nikolaus; Kozak, Igor; Maia, André; Maier, Mathias; Roizenblatt, Marina; Smiddy, William E; Sobol, Warren M; Freeman, William R
Abstract:: PURPOSE: To investigate closure rates and functional outcomes of surgery for refractory and recurrent macular holes (MHs) in a real-world setting. METHODS: Retrospective review of secondary MH surgeries. RESULTS: A total of 72 eyes from 72 patients were included. Eyes had a mean of 1.51 surgeries before inclusion into this study with a mean MH size of 762 µ m and a mean baseline logarithm of the minimum angle of resolution best-corrected visual acuity of 1.11 (∼20/260 Snellen). Closure rates were 89.3% for tissue transplantation, 77.3% for internal limiting membrane (ILM) flaps, 92.9% for MH manipulation, and 12.5% for repeat ILM peeling ( P < 0.05). Best-corrected visual acuity changes in logarithm of the minimum angle of resolution from baseline to postoperative month six were +0.29 for ILM peeling alone (15 Early Treatment Diabetic Retinopathy Study letters worse), -0.39 for MH manipulation (20 Early Treatment Diabetic Retinopathy Study letters improved), -0.23 for tissue transplantation (13 Early Treatment Diabetic Retinopathy Study letters improved), and -0.2 for ILM flaps (10 Early Treatment Diabetic Retinopathy Study letters improved; P < 0.05). CONCLUSION: Secondary MH closure is possible using various surgical techniques with acceptable anatomical closure rates. Repeat ILM peeling is associated with the lowest closure rates and poorest functional results. To distinguish between techniques would require a large sample size of approximately 750 eyes.
Journal title abbreviation:: Retina
Year:: 2023
Journal volume:: 43
Journal issue:: 4
Pages contribution:: 555-559
Fulltext / DOI:: doi:10.1097/IAE.0000000000003712
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/36727800
Print-ISSN:: 0275-004X
TUM Institution:: Klinik und Poliklinik für Augenheilkunde (Prof. Maier komm.)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Augenheilkunde (Prof. Maier komm.)2023