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Titel:

Immature human engineered heart tissues engraft in a guinea pig chronic injury model.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
von Bibra, Constantin; Shibamiya, Aya; Bähr, Andrea; Geertz, Birgit; Köhne, Maria; Stuedemann, Tim; Starbatty, Jutta; Horneffer-van der Sluis, Verena; Klostermeier, Ulrich C; Hornaschewitz, Nadja; Li, Xinghai; Wolf, Eckhard; Klymiuk, Nikolai; Krane, Markus; Kupatt, Christian; Hiebl, Bernhard; Eschenhagen, Thomas; Weinberger, Florian
Abstract:
Engineered heart tissue (EHT) transplantation represents an innovative, regenerative approach for heart failure patients. Late preclinical trials are underway, and a first clinical trial started recently. Preceding studies revealed functional recovery after implantation of in vitro-matured EHT in the subacute stage, whereas transplantation in a chronic injury setting was less efficient. When transplanting matured EHTs, we noticed that cardiomyocytes undergo a dedifferentiation step before eventu...     »
Zeitschriftentitel:
Dis Model Mech
Jahr:
2023
Band / Volume:
16
Heft / Issue:
5
Volltext / DOI:
doi:10.1242/dmm.049834
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37272385
Print-ISSN:
1754-8403
TUM Einrichtung:
Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Lange); Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz); Professur für Kardiovaskuläre Translation in Großtiermodellen (Prof. Klymiuk)
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