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Title:

Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Author(s):
Zheng, Yi; Yan, Robin Zhexuan; Sun, Shiyu; Kobayashi, Mutsumi; Xiang, Lifeng; Yang, Ran; Goedel, Alexander; Kang, Yu; Xue, Xufeng; Esfahani, Sajedeh Nasr; Liu, Yue; Resto Irizarry, Agnes M; Wu, Weisheng; Li, Yunxiu; Ji, Weizhi; Niu, Yuyu; Chien, Kenneth R; Li, Tianqing; Shioda, Toshihiro; Fu, Jianping
Abstract:
Despite its clinical and fundamental importance, our understanding of early human development remains limited. Stem cell-derived, embryo-like structures (or embryoids) allowing studies of early development without using natural embryos can potentially help fill the knowledge gap of human development. Herein, transcriptome at the single-cell level of a human embryoid model was profiled at different time points. Molecular maps of lineage diversifications from the pluripotent human epiblast toward...     »
Journal title abbreviation:
Cell Stem Cell
Year:
2022
Journal volume:
29
Journal issue:
9
Pages contribution:
1402-1419.e8
Fulltext / DOI:
doi:10.1016/j.stem.2022.08.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36055194
Print-ISSN:
1934-5909
TUM Institution:
Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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