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Title:

Thymosin ß4 and MRTF-A mitigate vessel regression despite cardiovascular risk factors.

Document type:
Article; Review; Journal Article
Author(s):
Kupatt, Christian; Ziegler, Tilman; Bähr, Andrea; Le Noble, Ferdinand
Abstract:
Since clinical revascularization techniques of coronary or peripheral artery disease (CAD/PAD) focus on macrovessels of the heart, the microcirculatory compartment largely goes unnoticed. However, cardiovascular risk factors not only drive large vessel atherosclerosis, but also microcirculatory rarefaction, an instance unmet by current therapeutic schemes. Angiogenic gene therapy has the potential to reverse capillary rarefaction, but only if the disease-causing inflammation and vessel-destabili...     »
Journal title abbreviation:
Int Immunopharmacol
Year:
2023
Journal volume:
117
Fulltext / DOI:
doi:10.1016/j.intimp.2023.109786
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36812671
Print-ISSN:
1567-5769
TUM Institution:
Klinik und Poliklinik für Innere Medizin I, Kardiologie
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