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Title:

Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma.

Document type:
Journal Article
Author(s):
Battaglia, Anna Martina; Sacco, Alessandro; Aversa, Ilenia; Santamaria, Gianluca; Palmieri, Camillo; Botta, Cirino; De Stefano, Roberto; Bitetto, Maurizio; Petriaggi, Lavinia; Giorgio, Emanuele; Faniello, Concetta Maria; Costanzo, Francesco; Biamonte, Flavia
Abstract:
Introduction: The PD-1/PD-L1 axis is hijacked by lung adenocarcinoma (LUAD) cells to escape immune surveillance. PD-L1 expression in LUAD is affected, among others, by the metabolic trafficking between tumor cells and the tumor microenvironment (TME). Methods: Correlation between PD-L1 expression and iron content within the TME was established on FFPE LUAD tissue samples. The effects of an iron rich microenvironment on PD-L1 mRNA and protein levels were assessed in vitro in H460 and A549 LUAD by...     »
Journal title abbreviation:
Front Cell Dev Biol
Year:
2023
Journal volume:
11
Fulltext / DOI:
doi:10.3389/fcell.2023.1208485
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37377735
TUM Institution:
Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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