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Title:

SOX2 promotes a cancer stem cell-like phenotype and local spreading in oral squamous cell carcinoma.

Document type:
Journal Article
Author(s):
Sacco, Alessandro; Battaglia, Anna Martina; Santamaria, Gianluca; Buffone, Caterina; Barone, Selene; Procopio, Anna; Lavecchia, Anna Maria; Aversa, Ilenia; Giorgio, Emanuele; Petriaggi, Lavinia; Cristofaro, Maria Giulia; Biamonte, Flavia; Giudice, Amerigo
Abstract:
Emerging evidence shows that oral squamous cell carcinoma (OSCC) invasiveness can be attributed to a small subpopulation of cancer stem cells (CSCs) in the bulk of the tumor. However, the presence of CSCs in the OSCC close resection margins is still poorly unexplored. Here, we found that BMI1, CD44, SOX2, OCT4, UBE2C, CXCR4 CSCs marker genes are significantly upregulated, while IGF1-R, KLF4, ALDH1A1, CD133, FAM3C are downregulated in the tumor core vs healthy mucosa of 24 patients with OSCC. Amo...     »
Journal title abbreviation:
PLoS ONE
Year:
2023
Journal volume:
18
Journal issue:
12
Fulltext / DOI:
doi:10.1371/journal.pone.0293475
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38096163
Print-ISSN:
1932-6203
TUM Institution:
Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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