User: Guest  Login
More Searchfields
Simple search
Title:

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zawada, Dorota; Kornherr, Jessica; Meier, Anna B; Santamaria, Gianluca; Dorn, Tatjana; Nowak-Imialek, Monika; Ortmann, Daniel; Zhang, Fangfang; Lachmann, Mark; Dreßen, Martina; Ortiz, Mariaestela; Mascetti, Victoria L; Harmer, Stephen C; Nobles, Muriel; Tinker, Andrew; De Angelis, Maria Teresa; Pedersen, Roger A; Grote, Phillip; Laugwitz, Karl-Ludwig; Moretti, Alessandra; Goedel, Alexander
Abstract:
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor populations. Understanding the specification and differentiation of these distinct progenitor pools during human embryonic development is crucial for advancing our knowledge of congenital cardiac malformations and designing new regenerative therapies. By combining genetic labelling, single-cell transcriptomics, and ex vivo human-mouse embryonic chimeras we uncovered that modulation of retinoic acid signaling i...     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-36764-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37012244
Print-ISSN:
2041-1723
TUM Institution:
Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Lange); Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz); Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
 BibTeX